CUFSAA-NA Distinguished Speaker Series
Table of Contents
- Distinguished Speaker Series – Talk 10 (February 27, 2024 at 9:30am Eastern Time) – Concluded
- Upcoming Talks of the Series
- List of All Concluded Talks
- Playlist of ALL Concluded Talks on Youtube
The Tenth Talk of the CUFSAA-NA Distinguished Speaker Series organized in association with the Faculty of Science, University of Colombo was delivered by Prof. Gomika Udugamasooriya on February 27, 2024, 09:30AM Eastern Time (February 27, 2024, 8:00pm Sri Lankan Time).
Event Flyer:
Join us LIVE!
Event Date & Time: February 27th 2024, 9:30AM Eastern Time (February 27th 2024, 8:00pm Sri Lankan Time (US and Canada)
How to Join: All talks of the Distinguished Speaker Series are FREE and delivered via Zoom Technology.
Zoom Link: https://us06web.zoom.us/j/83525537341?pwd=zdkAdZQIBVUdPzPislGwt522PuerfR.1
Meeting ID: 835 2553 7341
Passcode: 258158
Title: Novel technologies to expedite the drug-lead discovery process
Speaker: Gomika Udugamasooriya, PhD, Professor, Department of Pharmacological & Pharmaceutical Sciences, University of Houston, Houston, TX, USA, Cancer Systems Imaging, MD Anderson Cancer Center, Houston, TX, USA, The Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA and Senior Member, National Academy of Inventors, USA.
Abstract: In the conventional western drug discovery process, biologists first define disease specific biomarkers and then chemists and biologists develop drugs to target those biomarkers to attack the disease. According to statistics, only 1 out of initial 10,000 drug-leads become a drug, and this is a major concern in terms of effectiveness of the process. The vast majority of initially developed active drug-leads dropped away during the 5–15-year long drug discovery process, mainly due to their off-target effects. Dr. Udugamasooriya has developed a new on-bead two-color (OBTC) drug-lead discovery technology that can identify the most selective drug-leads at the very beginning, which can minimize the time and resource expenditures on validating those non-selective drug-leads. Various applications of this OBTC technology effectively bypass the conventional drug discovery approach that needs priori knowledge of the biomarker to develop drug-leads. The unbiased OBTC screens provide novel ways to identify new biomarkers and drug-leads to target those at the same time as well. This OBTC technology has so far produced 10 patented novel drug-candidates that are validated up to pre-clinical levels in Cancer, COVID19, Rheumatoid Arthritis, Alzheimer’s, Sepsis, and multiple other disease types.
Education: Dr. Gomika Udugamasooriya obtained his BSc (chemistry special) in 1999 from University of Colombo, Sri Lanka. He completed his PhD in Bioorganic chemistry and biochemistry in 2006 at Wayne State University, Michigan, USA. Then he completed a Post-Doctoral Fellowship at University of Texas – Southwestern Medical Center, Dallas, Texas, USA, mainly focusing on cancer chemical biology.
Research & Work Experience: In his independent academic career, Dr. Udugamasooriya first joined as a tenure track Assistant Professor at the University of Texas – Southwestern Medical Center, Dallas, Texas, USA in 2009. Then he moved to University of Houston (UH), MD Anderson Cancer Center and Baylor College of Medicine in Houston, USA, which is the world’s largest medical center, and currently serves as a tenured Professor of medicinal chemistry. The development of a unique high throughput cell screen to identify highly selective drug-leads for cell surface drug-targets was one of the major milestones in his career.
Professor Udugamasooriya is directing a multi-faceted research program mainly focused on cancer drug-lead discovery and diagnostic tool developments, funded by research grants from National Institute of Health (NIH), Department of Defense (DOD), Cancer Prevention and Research Institute of Texas (CPRIT), Innovative Research Award from the Rheumatology Research Foundation, Owens Foundation, Major Inc., and various other sources. He has published over 40 research articles so far in worlds topmost journals, including Nature Chemical Biology, Journal of American Chemical Society, Clinical Cancer Research and European Journal of Medicinal Chemistry etc. He also presented over 75 abstracts and gave about 50 invited seminars in US and worldwide. His novel drug discovery technology has so far produced 10 national and international patents.
Recognizing his impactful and innovative contributions to research and successes in patents and commercialization, he has been inducted as a Senior Member at the United States national Academy of Inventors in 2023, where only 435 Senior Members exist world-wide so far in the academy.
He is an editorial board member and a reviewer of many international scientific Journals. He is a member of grant review panels in US government National Institute of Health (NIH), Auckland Medical Research Foundation – New Zealand, US private foundations such as Keck Foundation and multiple international organizations. He received numerous awards, including Chancellor’s 50-in-5 Scholar multiple times at UH, Faculty Excellence in Research, NIH SPORE Cancer Excellence Career Development award, and in his undergraduate career, he graduated winning the gold medal award in chemistry at University of Colombo.
Professor Udugamasooriya was the Chair of the Graduate Education committee at UH. He has been an advocate for many young scientists and engage in numerous career building seminars and workshops both in US and Sri Lanka. He is actively engaged in conducting seminars and workshops worldwide on cancer prevention and research, highlighting the value of practicing holistic medical approaches. Those include developing good eating habits, building psychological strengths, positive thinking, in addition to conventional cancer treatments.
How to Join: All talks of the Distinguished Speaker Series are FREE and delivered via Zoom Technology.
Talk delivery: February 27th 2024, 9:30AM Eastern Time (February 27th 2024, 8:00pm Sri Lankan Time (US and Canada)
Zoom Link: Active during the Live Talk ONLY.
Time: Feb 27, 2024 9:30 AM Eastern Time (US and Canada) Join Zoom Meeting:https://us06web.zoom.us/j/83525537341?pwd=zdkAdZQIBVUdPzPislGwt522PuerfR.1 Meeting ID: 835 2553 7341 Passcode: 258158
Additional Ways to view: You can listen to the talk via FBLive and YouTube Live as well.
Prof. Hashini Perera, from the Department of Chemistry will deliver the vote of thanks on behalf of Prof. Rohini M. de Silva, Head of the Department of Chemistry, University of Colombo.
This talk will be moderated by Dr. Wasundara Fernando on behalf of the Speaker Series subcommittee of CUFSAA-NA.
Upcoming Talks of the Speaker Series for 2024
- Panel Discussion on Cancer Research
- Annual Graduate Application Guidelines Seminar
Please visit this webpage often to see updates and to join us at upcoming talks of the series.
List of All Concluded Talks of the Speaker Series
These are the concluded talks of the series available as on demand videos for you to view at your leisure.
- Talk 01: Dr. Nalin Samarasinha – Asteroid Colombounilanka and Contributions to Astronomy by University of Colombo – April 22, 2022:
- Talk 02: Prof. AP de Silva – From Chemistry to Medical Diagnostics and Information Processing – July 07, 2022:
- Talk 03: Dr. Jayeni Hiti-Bandaralage – A paradise on the iceberg – Entrepreneurship for innovators – August 28, 2022:
- Talk 04: Prof. David Hoskin – Iron withdrawal by selective chelators for cancer treatment – September 20, 2022:
- Talk 05: Dr. Binodh De Silva – Developing a Career as a Scientist in the Pharmaceutical Industry – November 09, 2022:
- Talk 06: Athula Alwis – The Role of InsureTech Startups in the US Commercial Insurance Industry – April 25, 2023:
- Talk 07: Panelists: Dr. Harshica Fernando, Dr. Arunika Gunawardena, Dr. Amita Manatunga, Dr. Unil Perera, and Dr. Kirthi Premadasa – Panel Discussion on Graduate Admissions to USA and Canada – July 12, 2023:
- Talk 08: Vajira Abeysinghe – Building a career in Information Technology – December 11, 2023:
- Talk 09: Prof. Sandun Perera – Enhancing your career options through data-driven or industry-focused research – January 29, 2024:
- Talk 10: Prof. Gomika Udugamasooriya – Novel technologies to expedite the drug-lead discovery process – February 27, 2024:
Listen to All Concluded Talks via Youtube
These are the concluded talks of the series available as on demand videos for you to view at your leisure. Please use the control buttons on the Youtube window below to navigate through and listen to ALL concluded Talks of the CUFSAA Distinguished Speaker Series.
For Example, You can click Once on the Playlist button on top righthand corner and skip to any concluded talk of your choice.